Search Result

Results for "

toxins A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (29) ADC Linker (1) Adenylate Cyclase (1) Adrenergic Receptor (1) Antibiotic (10) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (10) Arp2/3 Complex (1) ATP Synthase (1) Autophagy (1) Bacterial (20) Biochemical Assay Reagents (3) Calcium Channel (12) Caspase (3) Chloride Channel (1) Cholinesterase (ChE) (1) Dengue virus (1) DNA Alkylator/Crosslinker (6) DNA/RNA Synthesis (3) Dopamine Receptor (1) Drug-Linker Conjugates for ADC (8) EGFR (2) Endogenous Metabolite (15) Flavivirus (2) Fluorescent Dye (2) Formyl Peptide Receptor (FPR) (2) Fungal (5) GABA Receptor (3) HDAC (1) HIV Protease (1) HSP (2) iGluR (2) Isotope-Labeled Compounds (9) JNK (1) Keap1-Nrf2 (1) mAChR (7) Microtubule/Tubulin (14) Na+/K+ ATPase (1) nAChR (2) NF-κB (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) Parasite (4) PERK (1) Phosphatase (4) Phospholipase (1) Potassium Channel (20) ROS Kinase (1) SHP2 (2) Sodium Channel (28) Thyroid Hormone Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (7)
By Research Areas:	Cancer (68) Cardiovascular Disease (7) Endocrinology (2) Infection (45) Inflammation/Immunology (38) Metabolic Disease (15) Neurological Disease (62)
Click Chemistry:	DBCO (1)

226

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-P5152

*Scorpion toxin* Tf2**	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

HY-157328

7PCGY

Others Cancer

7PCGY is an ricin toxin A chain (RTA) inhibitor with an IC₅₀ value of 6?μM. 7PCGY can be used for the research of cell death .

7PCGY	Others	Cancer
7PCGY is an ricin toxin A chain (RTA) inhibitor with an IC₅₀ value of 6?μM. 7PCGY can be used for the research of cell death .

HY-P5917

Vm24-toxin Vaejovis mexicanus peptide 24	Potassium Channel	Others
Vm24-toxin is a toxin peptide that can be isolated from the Mexican scorpion Vaejovis mexicanus smithy. Vm24-toxin is an inhibitor of Kv1.3 potassium channel .

HY-N6729S2

*HT-2 Toxin-13C22*	Isotope-Labeled Compounds	Metabolic Disease
HT-2 Toxin- ¹³C₂₂ is ¹³C-labeled HT-2 Toxin (HY-N6729). HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants .

HY-P9957

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

HY-P4984

*Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)*	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a T cell proliferation activator. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) promotes the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in research on inflammatory and immunity, as well as cancer .

HY-N6729

HT-2 Toxin

Others Metabolic Disease

HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants .

HT-2 Toxin	Others	Metabolic Disease
HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants .

HY-P5807A

*Cn2 toxin* TFA** β-Mammal toxin Cn2 TFA	Sodium Channel	Neurological Disease
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .

HY-P5175

Muscarinic toxin 7

mAChR Neurological Disease

Muscarinic toxin 7 is a peptide toxin with selective and noncompetitive antagonism at the muscarinic M1 receptor .

*Muscarinic toxin* 7**	mAChR	Neurological Disease
Muscarinic toxin 7 is a peptide toxin with selective and noncompetitive antagonism at the muscarinic M1 receptor .

HY-P3071

ShK toxin	Potassium Channel	Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-P5857

MmTx2 toxin Micrurotoxin 2	GABA Receptor	Neurological Disease
MmTx2 toxin is a GABA_A receptor modulator that enhances GABA_A receptor sensitivity to agonists. MmTx2 toxin can be obtained from venom of coral snake. MmTx2 toxin can be used in the study of neurological diseases such as epilepsy, schizophrenia and chronic pain .

HY-126856

HC-Toxin

HDAC Apoptosis Cancer

HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell apoptosis and has anticancer effects .

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell apoptosis and has anticancer effects .

HY-P5782

δ-Theraphotoxin-Hm1a toxin	Sodium Channel	Neurological Disease
δ-Theraphotoxin-Hm1a toxin is a selective Na_v1.1 activator. δ-Theraphotoxin-Hm1a toxin elicits pain and touch sensitivity. δ-Theraphotoxin-Hm1a toxin can be used for the research of irritable bowel syndrome .

HY-130959

Tubulysin IM-2	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130960

Tubulysin IM-3	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-111431AS

p-Cresol sulfate-d7 potassium p-Tolyl sulfate-d₇ (potassium)	Endogenous Metabolite	Metabolic Disease
p-Cresol sulfate-d₇ (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].

HY-N6792

T-2 Toxin 1 Publications Verification T-2 Mycotoxin	Apoptosis DNA/RNA Synthesis	Metabolic Disease
T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD₅₀ values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW ^a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates . T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides . T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

HY-130958

Tubulysin IM-1	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis .

HY-124801

ABMA	Flavivirus Dengue virus Bacterial Parasite	Infection
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity .

HY-P5854

Aa1 toxin	Potassium Channel	Neurological Disease
Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .

HY-N6792S

*T-2 Toxin-13C24* T-2 Mycotoxin-¹³C₂₄	Isotope-Labeled Compounds	Metabolic Disease
T-2 Toxin- ¹³C₂₄ (T-2 Mycotoxin- ¹³C₂₄) is ¹³C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

HY-160791A

Claramine TFA	Others	Infection Cancer
Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins .

HY-160791

Claramine	Others	Infection Cancer
Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .

HY-121229A

(±)-Coniine

2-Propylpiperidine
Others Others

(±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock .
HY-132180

Seco-DUBA hydrochloride

ADC Cytotoxin Inflammation/Immunology Cancer

Seco-DUBA hydrochloride is a toxin for ADC drug SYD985 .
HY-P5942

Pterinotoxin-2

Sodium Channel Inflammation/Immunology

Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .
HY-P5943

Pterinotoxin-1

Sodium Channel Neurological Disease

Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

(±)-Coniine 2-Propylpiperidine	Others	Others
(±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock .

Seco-DUBA hydrochloride	ADC Cytotoxin	Inflammation/Immunology Cancer
Seco-DUBA hydrochloride is a toxin for ADC drug SYD985 .

Pterinotoxin-2	Sodium Channel	Inflammation/Immunology
Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .

Pterinotoxin-1	Sodium Channel	Neurological Disease
Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes *alpha-toxin* (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

HY-112779

Pertussis Toxin	Others	Infection
Pertussis Toxin is a protein-based AB₅-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins .

HY-15581

MMAD Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10	Microtubule/Tubulin ADC Cytotoxin	Cancer
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

HY-P2031

Phallacidin

Arp2/3 Complex Others

Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .
HY-126484

Eremofortin B

Others Others

Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .
HY-W001117

3,5-Dimethoxyphenol

Phloroglucinol Dimethyl Ether
Endogenous Metabolite Metabolic Disease

3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .
HY-125168

EGA

Others Infection Inflammation/Immunology

EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and virus[1].
HY-P10234

Poneratoxin

Sodium Channel Others

Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain .
HY-P0028

Phalloidin

5+ Cited Publications

Fluorescent Dye Others

Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

Eremofortin B	Others	Others
Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

EGA	Others	Infection Inflammation/Immunology
EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and virus[1].

Poneratoxin	Sodium Channel	Others
Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain .

Phalloidin 5+ Cited Publications	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

HY-P1441

Mambalgin 1	Sodium Channel	Others
Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation .

HY-121404A

Muscarine chloride (+)-Muscarine chloride	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system .

HY-121404

Muscarine (+)-Muscarine	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system .

HY-P5821

ω-Conotoxin CVIA

Calcium Channel Neurological Disease

ω-Conotoxin CVIA, a 27 amino acid neuropeptide toxin, is an voltage sensitive calcium channels blocker .
HY-P5822

ω-Conotoxin CnVIIA

Calcium Channel Neurological Disease

ω-Conotoxin CnVIIA, a 27 amino acid neuropeptide toxin, is a N-type calcium current blocker .
HY-78932

Dap-NE

Others Cancer

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162) .

ω-Conotoxin CVIA	Calcium Channel	Neurological Disease
ω-Conotoxin CVIA, a 27 amino acid neuropeptide toxin, is an voltage sensitive calcium channels blocker .

ω-Conotoxin CnVIIA	Calcium Channel	Neurological Disease
ω-Conotoxin CnVIIA, a 27 amino acid neuropeptide toxin, is a N-type calcium current blocker .

Dap-NE	Others	Cancer
Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162) .

HY-121404B

Muscarine tosylate (+)-Muscarine tosylate	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system .

HY-130476

Satratoxin G

Caspase Apoptosis Cancer

Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

Satratoxin G	Caspase Apoptosis	Cancer
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-P5860

MmTx1 toxin Micrurotoxin 1	GABA Receptor	Neurological Disease
MmTx1 toxin (Micrurotoxin 1) is an allosteric GABA_A receptor modulator that increases GABA_A receptor susceptibility to agonist .

HY-P5925

Ssm spooky toxin SsTx Toxin	Potassium Channel	Inflammation/Immunology
Ssm Spooky Toxin from?Scolopendra mutilans, exhibits lethal toxicity in hematological and respiratory systems by potently inhibiting KCNQ (voltage-gated potassium channel family 7) channels, with IC₅₀? of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .

HY-P1446

Cholera toxin 5+ Cited Publications Choleragen	Adenylate Cyclase	Inflammation/Immunology
Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER) . Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein .

HY-148193

Tubulin polymerization-IN-38	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs .

HY-P5144

Aah II

Sodium Channel Inflammation/Immunology

Aah II is a sodium channel modulator. Aah II is a toxin that can be isolated from the venom of scorpion Androctonus australis .

Cat. No.	Product Name	Target	Research Area

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-P99277

Actoxumab Anti-C. difficile Toxin A Recombinant Antibody	Inhibitory Antibodies	Infection
Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB .

HY-P9957

Raxibacumab ABthrax	Bacterial	Infection
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .

HY-P99551

Tosatoxumab KBSA301; AR-301	Antibiotic	Infection
Tosatoxumab (AR-301; KBSA301) is a human immunoglobulin G1 monoclonal antibody that specifically neutralizes *alpha-toxin* (alpha-hemolysin; Hla) of S. aureus. Tosatoxumab binds to an N-terminal epitope of alpha-toxin, thereby preventing functional toxin pore oligomerisation. Tosatoxumab has the potential for passive immunotherapy in the S. aureus pneumonia as an adjunctive therapy to standard antibiotic agent .

HY-P99800

Pritoxaximab

Inhibitory Antibodies Infection

Pritoxaximab is an IgG1κ antibody targeting shiga toxin type 1 .
HY-P99532

Urtoxazumab

HuVTm1.1; TMA-15
Inhibitory Antibodies Infection

Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against Shiga toxin (Stx) 2 .
HY-P99447

Atidortoxumab

Inhibitory Antibodies Infection

Atidortoxumab is a human IgG1κ monoclonal antibody that targets Staph aureus alpha toxin .
HY-P99898

Setoxaximab

Inhibitory Antibodies Others

Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1 .

HY-P99583

Suvratoxumab MEDI4893	Bacterial	Infection Inflammation/Immunology
Suvratoxumab (MEDI4893) is a long-acting, high-affinity *human anti-α-toxin* monoclonal antibody** (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .

HY-P9932

Obiltoxaximab ETI 204	Inhibitory Antibodies	Infection
Obiltoxaximab is a potent anti-protective antigen (PA) monoclonal antibody. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication. Obiltoxaximab can be used in animal‐to‐human dose translation for research of inhalational anthrax .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6729

HT-2 Toxin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Agrostidoideae Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Others
HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants .

HY-N6792

T-2 Toxin 1 Publications Verification T-2 Mycotoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	Apoptosis DNA/RNA Synthesis
T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD₅₀ values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BW ^a,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates . T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides . T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

HY-P2031

Phallacidin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Arp2/3 Complex
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

HY-121229A

(±)-Coniine 2-Propylpiperidine	Alkaloids Piperidine Alkaloids Tsuga chinensis (Franch.) Pritz. Classification of Application Fields Pinaceae Source classification Other Diseases Plants Disease Research Fields	Others
(±)-Coniine, a piperidine alkaloid, is a toxin found in poison hemlock .

HY-126484

Eremofortin B	Structural Classification Natural Products Microorganisms Source classification	Others
Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .

HY-W001117

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Schisandra sphenanthera Rehd. et Wils Monophenols Classification of Application Fields Source classification Taxaceae Phenols Metabolic Disease Plants Schisandraceae Disease Research Fields Taxus chinensis (Pilger) Rehd.	Endogenous Metabolite
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase .

HY-N6721

T-2 Tetraol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Others
T-2 Tetraol is a metabolite of T-2 toxin, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis .

HY-N6720

T-2 Triol	Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
T-2 Triol is a trichothecene mycotoxin derived by the metabolism of T-2 toxin. It is less toxic than T-2 toxin . T-2 Triol major metabolites are evaluated in broiler chickens with Half-lives (t_1/2λz), Peak plasma concentrations (C_max) and T_max values of 9.6 mins, 563 ng/ml , 2.5 mins, respectively .

HY-N5121

Calycanthine 1 Publications Verification	Alkaloids Structural Classification Source classification Calycanthacerae Plants Chimonanthus praecox (L.)Link Alkaloid Dimers	Endogenous Metabolite
Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus Psychotria, and is a central nervous system toxin, causing convulsions .

HY-111431

p-Cresyl sulfate 1 Publications Verification p-Tolyl sulfate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

HY-N10546

Ganglioside GM1	Structural Classification Natural Products Animals	Others
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-N6774

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-N7719

Oosporein	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Benzene Quinones Disease Research Fields	Endogenous Metabolite
Oosporein is a red crystalline metabolite produced by a toxin-producing strain of Chaetomium trilaterale. Chaetomium trilaterale is isolated from moldy Peanuts. Oosporein inhibits plant growth and produces phytotoxic effects .

HY-P0219

Microcystin-LA	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Phosphatase
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively .

HY-W015343

3-Methoxyphenylacetic acid m-Methoxyphenylacetic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot .

HY-N11682

Microcystin-LY	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Keap1-Nrf2
Microcystin-LY, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa , acts as an activator of the Nrf2 pathway to induce oxidative stress response, and the induction effect is most obvious at 3μM. .

HY-111431A

p-Cresyl sulfate potassium 1 Publications Verification p-Tolyl sulfate potassium	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite JNK p38 MAPK
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

HY-N2387

Pinosylvin	Infection Stilbenes Classification of Application Fields Polygonaceae Source classification Reynoutria japonica Houtt. Phenols Polyphenols Plants Disease Research Fields	Bacterial Apoptosis Autophagy
Pinosylvin is a pre-infectious stilbenoid toxin isolated from the heartwood of Pinus species, has anti-bacterial activities . Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells .

HY-119412

Biliatresone	Structural Classification Flavonoids other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Isoflavones	Others
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model .

HY-111009

Swinholide A	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-N11667

18-O-Demethylpederin	Structural Classification Natural Products Source classification Marine natural products Other marine organisms	Others
18-O-Demethylpederin is a pederin analogue. Pederin is a natural polyketide compound extracted from Paederus for the first time. It is a non-protein insect toxin with a broad spectrum of biological activities, including antibacterial, antiviral, and antitumor .

HY-N10511

GM1a Ganglioside oligosaccharide	Structural Classification Natural Products Polysaccharides Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Others
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-N6688

Verruculogen	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Potassium Channel Bacterial Antibiotic
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca ²⁺-activated K ⁺ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .

HY-P3065

Calcicludine	Structural Classification Natural Products Animals Source classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba Dendroaspis angusticeps that inhibits high-voltage-activated calcium channel, especially L-type calcium channel with the IC₅₀ of 88 nM. Calcicludine has role in excitatory synaptic transmission .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Derris indica	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-107222

Lysionotin	Gesneriaceae Structural Classification Lysinonotus pauciflorus Maxim. Flavonoids Classification of Application Fields Flavones Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Lysionotin is a flavonoid isolated from Gesneriaceae family. Lysionotin efficiently inhibit *α-Toxin* (a pore-forming protein) expression and shows significant protection against S. aureus in vitro and in vivo. Lysionotin has the potential for the treatment of S. aureus induced pneumonia .

HY-W040307

Saccharopine L-Saccharopine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .

HY-W040307B

Saccharopine hydrochloride L-Saccharopine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .

HY-122009

Indican Indoxyl-β-D-glucoside	Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids Indigofera	Fluorescent Dye
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 .

HY-W145518

Pectin	Structural Classification Natural Products Classification of Application Fields Source classification Rosaceae Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Polysaccharides Microorganisms Malus pumila Mill. Disease Research Fields Saccharides	Endogenous Metabolite Bacterial Antibiotic
Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa .

HY-N6745

Citreoviridin	Cardiovascular Disease Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-N6801

Nivalenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Inflammation/Immunology Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-135416

Streptolysin O	Infection Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-42682

D(+)-Galactosamine hydrochloride 1 Publications Verification D-Galactosamine hydrochloride	Microorganisms Source classification Vitis vinifera cv. Zalema Plants Vitaceae Inflammation/Immunology Disease Research Fields Saccharides	Others
D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .

HY-P1280

Margatoxin	Natural Products Animals Neurological Disease Source classification Disease Research Fields	Potassium Channel
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-135416A

Streptolysin O (≥1000000 units/mg)	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-N6785

Okadaic acid Maximum Cited Publications 7 Publications Verification	Structural Classification Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation .

Cat. No.	Product Name	Chemical Structure

HY-111431AS

p-Cresol sulfate-d7 potassium
p-Cresol sulfate-d₇ (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].

HY-N6729S2

*HT-2 Toxin-13C22*
HT-2 Toxin- ¹³C₂₂ is ¹³C-labeled HT-2 Toxin (HY-N6729). HT-2 Toxin is an active, deacetylated metabolite of the T-2 toxin. HT-2 toxin inhibits protein synthesis and cell proliferation in plants .

HY-N6792S

T-2 Toxin-13C24

T-2 Toxin- ¹³C₂₄ (T-2 Mycotoxin- ¹³C₂₄) is ¹³C-labeled T-2 Toxin (HY-N6792). T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues .

HY-42682S1

D(+)-Galactosamine-13C hydrochloride
D(+)-Galactosamine- ¹³C (hydrochloride) is the ¹³C labeled D(+)-Galactosamine hydrochloride. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and

HY-107654S

Muscarine-d9 iodide
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].

HY-136406S

Bongkrekic acid-13C28
Bongkrekic acid-13C28 is the C13 labeled Bongkrekic acid. Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-103447S1

Zearalenone-13C18
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N6801S

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-23155S

2-Phenylethyl isothiocyanate-d5

2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

HY-B1455S

Clindamycin-d3 hydrochloride

Clindamycin-d₃ (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2].

HY-B1455S1

Clindamycin-13C,d3

Clindamycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks